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What factors of GLP-1 coverage drive up premiums Using data from MarketScan and research by Blue Health Intelligence (BHI), the EBRI report models how GLP-1 coverage could affect employer-sponsored insurance premiums, exploring several scenarios based on: Drug pricing Net costs range from $617 to $766 per 30-day supply Patient adherence Perfect adherence leads to higher premiums due to sustained drug use Eligibility criteria Including overweight individuals with at least one weight-related condition significantly increases cost burden Cost-sharing Cost-sharing structures such as $90 copays help but dont eliminate increases Usage is growing More than 57 million privately insured adults qualify for GLP-1 drugs, like Ozempic and Wegovy

17 Indeed, pharmacologic responses to GIPRAs alone in patients with T2DM have been clinically disappointing with respect to improvements in glucose and cardiorenal outcomes

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A.et al (2014)

Because P-5-P does not require enzymatic conversion in the liver, it is immediately available for use in the transsulfuration pathway and does not carry the same toxicity risks associated with high-dose pyridoxine